The Lecture provides a comprehensive overview of tuberculosis (TB) epidemiology up to 2025, highlighting its global impact and specific regional data. It discusses the worldwide burden of TB. The Lecture emphasizes the persistent challenges posed by TB, including drug resistance, HIV co-infection, and socioeconomic factors that increase vulnerability. It outlines the global strategic goals and the End TB Strategy. An information on TB transmission modes, pathogenesis, risk groups, and the impact of COVID-19 on TB control presented.