TABLE OF COEFFICIENTS OF SUBSTITUTION OF FAT BASE
The coefficients of substitution of fat-based for some
drugs
|
№ p / p |
The drug substance |
COEFFICIENT |
1 / Coefficient |
|
|
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
quinacrine Amidopyrine analgene anestezin Antipyrine apilak barbamil barbital Barbital-sodium Basic bismuth nitrate Glucose dermatol iron lactate Ichthyol calcium gluconate Camphor calcium lactate Aluminum potassium alum ascorbic acid boric acid Vinilkamennaya acid (tartaric) citric acid cocaine hydrochloride |
1.59 1.15 1.27 1.33 1.25 1.48 1.81 1.06 1.81 4.80 1.23 2.60 1.59 1.10 2.01 0.98 1.53 1.8 1.73 1.6 1.03 1.27 1.18 |
0.63 0.87 0.79 0.75 0.80 0.68 0.55 0.94 0.55 0.21 0.81 0.38 0.63 0.91 0.50 1.02 0.65 0.56 0.58 0,625 0.97 0.79 0.85 |
|
|
Continuation of table 4 |
||||
|
one |
2 |
3 |
four |
|
|
24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
Xeroform chloramphenicol foxglove leaves castor oil Menthol morphine hydrochloride sodium bromide sodium bicarbonate Novocaine Osarsol papaverine hydrochloride Paraffin Protargolum resorcinol sulfur precipitated sulfathiazole Tannin theophylline phenobarbital Phenol furazolidone quinine hydrochloride hinozol Chloral hydrate zinc oxide zinc sulfate eufillin |
4.8 1.59 1.81 1.0 1.09 1.18 2.22 2.12 1.40 1.45 1.59 1.0 1.4 1.41 1.41 1.61 0.9 1.23 1.4 1.1 1.81 1.2 1.36 1.5 4.0 2.0 1.25 |
0.21 0.63 0.55 1.0 0.92 0.85 0.45 0.47 0.71 0.69 0.63 1.0 0.71 0.71 0.71 0.62 1.1 0.81 0.71 0.91 0.55 0.83 0.74 0.67 0.25 0.5 0.8 |
|
Note 1. Coefficient - number of grams of the drug, which occupies the same volume as 1 g fat base;
1 / Coefficient - number of grams of fat base, which occupies the same volume as 1 g of the drug substance.
1.21 - module transition from fat base to gelatin-glycerin (equal to the relative density gelatin-glycerin basic - 1.15 - fat base to density - 0.95).
2. For compounds with coefficient less than 1.1 calculations substitution inexpedient.
